Table 3.

The acrophase and the corresponding peak time of BMAL1 and CLOCK protein expression by using the Cosinor model.

BMAL1			p -value of acrophase
Group	Acrophase (estimates ± SE)	Peak time (h)	Sham vs. 6-OHDA	6-OHDA vs. 6-OHDA+L-dopa	Sham vs. 6-OHDA+L-dopa
Sham	2.8036 ± 0.5333	10.7	0.3442	0.0834	0.4947
6-OHDA	2.0881 ± 0.5207	8.0
6-OHDA+L-dopa	3.2535 ± 0.3823	12.4
CLOCK			p -value of acrophase
Group	Acrophase (estimates ± SE)	Peak time (h)	Sham vs. 6-OHDA	6-OHDA vs. 6-OHDA+L-dopa	Sham vs. 6-OHDA+L-dopa
Sham	2.4799 ± 0.2111	9.5	0.4949	0.1016	0.1344
6-OHDA	2.1530 ± 0.4446	8.2
6-OHDA+L-dopa	3.5475 ± 0.7178	13.6

L-dopa, L-3,4-dihydroxyphenylalanine.