Table 3.

Association of clinicopathological variables and subgroups with disease-free survival and overall survival in the first cohort in univariate and multivariate analyses.

Variables		a. Univariate analysis			b. Multivariate analysis			c. Univariate analysis			d. Multivariate analysis
		HR	95%CI	p value	HR	95%CI	p value	HR	95%CI	p value	HR	95%CI	p value
		Disease-free survival						Overall survival
Sex	Woman vs man	1.420	0.807-2.477	0.2207				1.456	0.674-3.126	0.3335
Location	Rectum vs Left colon	1.488	0.784-2.864	0.2238				1.336	0.549-3.429	0.5257
	Right colon vs Left colon	1.671	0.778-3.476	0.1821				1.411	0.492-3.950	0.5104
	Right colon vs Rectum	1.123	0.534-2.260	0.7508				1.056	0.393-2.627	0.9084
pT	pT4 vs pT3	1.488	0.646-3.007	0.3261				2.477	0.967-5.630	0.0581
Stage	III vs II	2.319	1.299-4.322	0.0041	1.816	0.981-3.520	0.0577	2.575	1.139-6.570	0.0222	2.264	0.972-5.923	0.0586
Histological type	MUC vs WDA	10.443	1.857-58.726	0.0253	9.556	1.537-59.396	0.0350	4.994	0.448-55.676	0.2455
Lymphatic invasion	Positive vs Negative	2.444	0.895-10.069	0.0865				3.596	0.762-64.238	0.1226
Venous invasion	Positive vs Negative	1.473	0.643-4.255	0.3878				1.677	0.499-10.431	0.4493
Tumor budding	High vs Low	1.386	0.707-2.548	0.3275				1.502	0.636-3.299	0.3383
Desmoplastic reaction	Immature vs Intermediate	1.766	0.894-3.446	0.1003				1.788	0.725-4.257	0.2004
	Immature vs Mature	3.023	1.486-6.183	0.0025	2.190	1.012-4.793	0.0467	3.660	1.316-10.947	0.0132	2.473	0.821-7.870	0.107
	Intermediate vs Mature	1.711	0.869-3.435	0.1200				2.048	0.793-5.893	0.1407
Subgroup	Subgroup 1 vs 2	3.626	1.860-7.224	0.0002	3.012	1.512-6.127	0.0018	2.643	1.082-6.459	0.0335	2.082	0.825-5.261	0.1185
	Subgroup 1 vs 3	2.024	1.036-4.049	0.0392	1.710	0.819-3.672	0.1538	2.058	0.789-5.676	0.1393
	Subgroup 3 vs 2	1.791	0.868-3.697	0.1135				1.284	0.466-3.347	0.6154

WDA, well-differentiated adenocarcinoma; MUC, mucinous carcinoma; HR, hazard ratio; 95%CI, 95% confidence interval.