Table 4.
Association of clinicopathological variables and individual marker with disease-free survival and overall survival in the first cohort in univariate and multivariate analyses.
| Variables | a. Univariate analysis | b. Multivariate analysis | c. Univariate analysis | d. Multivariate analysis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | p value | HR | 95%CI | p value | HR | 95%CI | p value | HR | 95%CI | p value | ||
| Disease-free survival | Overall survival | ||||||||||||
| Stage | III vs II | 2.319 | 1.299-4.322 | 0.0041 | 1.760 | 0.943-3.430 | 0.0762 | 2.575 | 1.139-6.570 | 0.0222 | 2.237 | 0.959-5.856 | 0.0629 |
| Histological type | MUC vs WDA | 10.443 | 1.857-58.726 | 0.0253 | 15.097 | 2.505-90.973 | 0.0132 | 5.001 | 0.929-33.667 | 0.2451 | |||
| Desmoplastic reaction | Immature vs Intermediate | 1.766 | 0.894-3.446 | 0.1003 | 1.788 | 0.725-4.257 | 0.2004 | ||||||
| Immature vs Mature | 3.023 | 1.486-6.183 | 0.0025 | 2.358 | 1.115-5.033 | 0.0250 | 3.660 | 1.316-10.947 | 0.0132 | 3.076 | 1.085-9.352 | 0.0347 | |
| Intermediate vs Mature | 1.711 | 0.869-3.435 | 0.1200 | 2.048 | 0.793-5.893 | 0.1407 | |||||||
| α-SMA | Positive vs Negative | 0.684 | 0.250-2.821 | 0.5468 | 0.628 | 0.187-3.905 | 0.5532 | ||||||
| CD10 | Positive vs Negative | 1.690 | 0.798-3.254 | 0.1606 | 1.412 | 0.472-3.453 | 0.5025 | ||||||
| Podoplanin | Positive vs Negative | 1.019 | 0.583-1.821 | 0.9477 | 1.039 | 0.486-2.307 | 0.9215 | ||||||
| FSP1 | Positive vs Negative | 0.677 | 0.209-4.150 | 0.6111 | 0.357 | 0.072-6.461 | 0.3876 | ||||||
| FAP | Positive vs Negative | 0.501 | 0.120-1.392 | 0.2067 | 0.278 | 0.154-1.334 | 0.1270 | ||||||
| Tenascin-C | Positive vs Negative | 2.694 | 1.293-6.557 | 0.0065 | 2.317 | 1.068-5.870 | 0.0324 | 2.052 | 0.840-6.130 | 0.1201 | |||
| PDGFR-β | Positive vs Negative | 0.988 | 0.550-1.863 | 0.9680 | 0.764 | 0.351-1.786 | 0.5176 | ||||||
| ZEB1 | Positive vs Negative | 1.269 | 0.584-3.325 | 0.5730 | 2.094 | 0.623-13.018 | 0.2638 | ||||||
| TWIST1 | Positive vs Negative | 1.512 | 0,851-2.639 | 0.1554 | 1.185 | 0.533-2.540 | 0.6673 | ||||||
| Ki-67 | Positive vs Negative | 1.139 | 0.653-2.011 | 0.6477 | 1.245 | 0.579-2.736 | 0.5754 | ||||||
| p53 | Positive vs Negative | 0.629 | 0.359-1.098 | 0.1023 | 0.504 | 0.231-1.077 | 0.0767 | ||||||
| MMP7 | Positive vs Negative | 1.621 | 0.890-3.069 | 0.1096 | 1.205 | 0.560-2.734 | 0.6383 | ||||||
| β-catenin | Positive vs Negative | 0.770 | 0.401-1.395 | 0.3974 | 0.979 | 0.419-2.127 | 0.9578 | ||||||
| E-cadherin* | |||||||||||||
| HIF1-α | Positive vs Negative | 0.461 | 0.101-8.172 | 0.4961 | 0.297 | 0.062-5.344 | 0.3187 | ||||||
WDA, Well-differentiated adenocarcinoma; MUC, mucinous carcinoma; HR, Hazard ratio; 95%CI, 95%confidence interval. *could not analyze, why all cases were positive expression of the marker.