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. 2021 Aug 19;15:693861. doi: 10.3389/fnins.2021.693861

FIGURE 1.

FIGURE 1

Experimental setup. (A) Experimental protocol – functional electrical stimulation therapy (FEST) was delivered over the course of 12-weeks with three sessions per week and each session lasting 45–60 min. Long-term assessments were carried out at baseline (Pre), after 6- and 12-weeks of FEST (During and Post0), as well as during follow-up 6- and 12-weeks after FEST (Post1 and Post2) and they included: functional magnetic resonance imaging (fMRI), transcranial magnetic stimulation (TMS), drawing tests, and clinical test evaluations. Short-term assessments were carried out once per week over the course of 12-weeks to compare before and after each FEST session using TMS assessments. (B) Each FEST training session consisted of three functional training protocols including the palmar grasp – to generate hand opening, hand-mouth – to generate elbow and shoulder flexion, and point forward – to generate hand pointing forward, by activating a sequence of muscles activations.