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. 2021 Aug 23;3(3):fcab192. doi: 10.1093/braincomms/fcab192

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Neuropathology analysed by seizure type and lifetime GTCS burden. (A) The percent of known cases with focal only, generalized only, or mixed seizure types in epilepsy overall (regardless of cause of death; COD). (B) The number of neuropathology findings per case in each seizure type group is not significantly different (one-way ANOVA). (C) Brain weight in each seizure type group is not significantly different (one-way ANOVA). (D) The percent of cases with neuropathology findings in each seizure type group are depicted for the diagnoses described on the x-axis. For the focal only group, the most frequent finding was FCD (43.8%). For the generalized only group, the most frequent finding was DGD (46.2%). For the mixed seizure types group, the most frequent findings were FCD (40.0%) and hippocampal sclerosis (40.0%). (E) The percent of known cases with lifetime GTCS burden in epilepsy overall (regardless of COD). (F) The number of neuropathology findings per case in each GTCS group is not significantly different (one-way ANOVA). (G) Brain weight in each GTCS group is not significantly different (one-way ANOVA). (H) The percent of cases with neuropathology findings in each GTCS group are depicted for the diagnoses described on the x-axis. For the majority of the GTCS groups (10–100, 100–500), the most frequent finding was FCD. For the cases with <10 lifetime GTCS, the most frequent finding was DGD. For cases with >500 lifetime GTCS, the most frequent diagnosis was no abnormality. For the cases with 0 lifetime GTCS, the most frequent findings were FCD and infarct. The mean is depicted with errors bars representing SEM.