Table 4.
Comparison of neuropathology findings to previous cohort
| Series | Thom 20164 | NASR cohort | ||
|---|---|---|---|---|
| Number of cases | 145a | 61b | ||
| Average | Range | Average | Range | |
| Age at death range (years) | 40.0 | 2–82 | 30.0 | 3–57 |
| Age of onset | 17.9 | 0–82 | 15.3 | 0–56 |
| Disease duration | 23.2 | 1–74 | 17.8 | 1–55 |
| Male (% cases) | 61.1% | 65.6% | ||
| Cases with whole brain fixed | 76.6 | 100.0 | ||
| Cases with brain histology | 100.0 | 100.0 | ||
| Brain swelling | 28.3 | 0.0 | ||
| Microscopic findings | 89.0 | 75.4 | ||
| Traumatic lesions | 16.6 | 4.9 | ||
| Cortical malformations | 14.5 | 42.6 | ||
| Vascular malformations | 4.9 | |||
| Hippocampal sclerosis | 21.4 | 11.5 | ||
| Old infarcts | 6.9 | 9.8 | ||
| CNS tumors | 13.0 | 0.0 | ||
| Cerebellar atrophy | 40.7 | 0.0 | ||
| Hippocampal rotation | 9.7 | 3.3 | ||
| Acute hypoxic-ischaemic change | 55.2 | 1.6 | ||
| No pathology findings | 11.0 | 24.6 | ||
| External findings/general PM examination | ||||
| Pulmonary findings | 68.0 | 90.4 | ||
| Cardiac findings | 63.5 |
Cortical malformations include FCD, heterotopias and polymicrogyria. Vascular malformations include telangiectasia and venous angioma.
a
One hundred and eleven without possible/near/combined SUDEP cases.
b
Fifty-five without possible SUDEP.