FIGURE 1.

Host susceptibility to invasive fungal infection: predisposing factors and treatment approach. Schematic diagram represents predisposition of the host to certain factors that make them susceptible to fungal infections. Such factors can be genetic as well as non-genetic. Apart from genetic mutations in the host ligand, fungal receptors, and immune genes, human ancestry plays an important role in susceptibility toward invasive fungal infections. The future approaches would be geared toward the investigation (as part of preventive medicine) of the genetic mutations that predispose individuals to fungal infections and offer personalized medicine compared to the more traditional approach that is practiced in the form of antifungal medication.