FIGURE 1.

Basal extracellular DA, 5-HT, and their metabolites levels in the striatum in awake FFAR1+/+ and −/− mice. FFAR1 −/− mice showed significantly elevated basal DA level (A). All metabolites of DA, DOPAC (C), 3-MT (D), and HVA (E) also showed significantly increased levels in −/− mice. Mean baseline 5-HT level (B) was substantially reduced in −/− mice, but those of 5-HT metabolite, 5-HIAA (F), did not differ significantly between the two genotypes. *p < 0.05, **p < 0.01 vs. +/+ mice (Student’s t-test). n = 17 for +/+ mice, and n = 16 for −/− mice.