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. 2021 Aug 20;12:699813. doi: 10.3389/fpsyt.2021.699813

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Copyright © 2021 Park, Haak, Cho, Valk, Bethlehem, Milham, Bernhardt, Di Martino and Hong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age by group interaction effects in the connectivities showing significant group differences in previous seed-based analyses. (A) Hypoconnectivity among low-level sensory/motor regions in ASD compared to NT was consistently observed across age, but there was no significant interaction effect (F = 0.03, p = 0.85). (B) Hyperconnectivity among low-level cortico-subcortical network connections became increasingly more severe across age in ASD, revealing a significant interaction effect (F = 5.27, p = 0.02). (C) Hypoconnectivity among high-order networks in ASD showed a less severe pattern with age, resulting in a significant interaction effect (F = 4.04, p < 0.05) (D) Hyperconnectivity among high-order networks in ASD showed an increasing age-dependent trend, yet no significant interaction effect (F = 1.27, p = 0.26).