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. 2021 Aug 20;12:687291. doi: 10.3389/fimmu.2021.687291

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Copyright © 2021 Fang and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Target pathway crosstalk identified in kidney stone disease. (A) Gene-centric representation of the crosstalk, with nodes for genes and edges for interactions between nodes. Node are labelled by gene symbols along with the priority information (formatted as “rating@rank”) and colored by priority rating. This crosstalk was identified to contain highly prioritized interconnecting genes from a network of gene interactions (obtained by merging KEGG pathways). (B) Pathway-centric representation of the crosstalk, with nodes for pathways (sized by the number of member genes) and edges for connections (the thickness proportional to the number of genes shared between two-endpoint pathways). Also labeled in the edges are shared genes between the TNF signaling and the other endpoint as indicated.