Figure 2.

Global characteristics of tumor microenvironment and immunotherapeutic perspectives in GIST. PGFRα: platelet derived growth factor receptor α, SDH, succinate dehydrogenase; NF1, Neurofibrimin 1; NK cell, Natural killer cells; IDO, Indoleamine 2,3-dioxygenase; MHC, Major histocompatibility complex; ICP, Immune checkpoint protein; VEGF, vascular endothelium growth factor; IFN- γ, Interferon- γ; TLS, Tertiary lymphoid structure; PD-1, programmed cell death 1; TIM-3, T-cell immunoglobulin and mucin containing protein-3; LAG-3, Lymphocyte-Activation Gene 3; GITR, Glucocorticoid-Induced TNFR-Related protein; ICOS, Inducible T-cell costimulatory; TIGIT, T cell immunoreceptor with Ig and ITIM domains); BITEs, Bispécific T cell Engager antibodies; ICI, immune checkpoint inhibitors.