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Therapeutic options in the treatment of gastrointestinal stromal tumors (NCCN Guidelines, October 2020).
| Phase | Setting | Treatment |
|---|---|---|
| Localized disease | (Neo-)Adjuvant | Imatinib |
| PGFRα-D842V: Avapritinib | ||
| Advanced disease | First-line setting | Imatinib |
| PGFRα-D842V: Avapritinib | ||
| Second-line setting | Sunitinib | |
| Third-line setting | Regorafenib | |
| Fourth-line setting | Ripretinib | |
| Other options | Avapritinib | |
| Cabozantinb | ||
| Dasatinib | ||
| Nilotinib | ||
| Pazopanib |
