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The structure of SFRP genes and proteins. The diagram shows SFRP1, SFRP2 and SFRP5 each containing three exons, but SFRP3 and SFRP4 containing six exons. SFRPs have common structural features with a signal peptide comprising 20-30 amino acids, a cysteine rich domain (CRD) and a netrin like domain (NTR).
