| SFRP1-/-
|
Enhances trabecular bone formation in adults. Telencephalic Patterning, growth and differentiation. Promotes normal alveolar formation in lung development. Enhances mammary gland inflammation in response to obesity Mediates mammary epithelial apoptotic response to DNA damage. Maintains proper mammary gland development. Improves fracture healing Regulates the tumors progression in murine mammary epithelial cells. Regulates the progression of renal fibrosis. Regulates cycling activity and maintenance of hematopoietic stem cells. Leads to deterioration of cardiac function in aged mice. Regulates the cancer stem cells proliferation and metastasis in skin cancer. Contributes to the development of brain, kidney and skeleton.
|
Wnt signaling in osteoblasts Wnt and Notch signaling in hippocampal. Wnt and ERK signaling in lung tissue. Wnt and apoptosis in breast cancer of obesity. P53 target genes pathway in mammary epithelial cells. Wnt and downstream regulators in mammary gland. Wnt signaling in bone formation. Wnt and TGFβ signaling pathway. Non-canonical Wnt/PCP pathway. Extrinsic regulation of β-catenin. Wnt signaling pathway in cardiac tissue. EMT regulators and growth factor signaling. Wnt signaling pathway.
|
(68–80) |
| SFRP2-/-
|
Contributes to the development of primary aldosteronism. Controls fibrosis in myocardial infarction. Plays a critical role in proper distal limb formation. Modulates cell fate of the murine intestinal epithelium
|
Wnt signaling pathway. Enhanced procollagen C-proteinase activity. Wnt/β-catenin signaling pathway. Wnt/β-catenin signaling pathway
|
(81–84) |
| SFRP3-/-
|
Controls post-natal mammary gland morphogenesis. modulates the progressive weakness and muscle degeneration. As a molecular target of antidepressant treatments in rodent models. Regulates cell development of articular cartilage - subchondral bone unit. Contributes to the development of osteoarthritis. Reduces voluntary running exercise performance in mice. Regulates quiescent adult hippocampal neural stem cell activation. Promotes the osteogenesis
|
Wnt/β-catenin signaling pathway. Wnt/β-catenin signaling pathway. Wnt/β-catenin signaling pathway. Wnt/β-catenin signaling pathway. Increase the activity of MMPs. Increased Wnt activity and MMPs. Increased RGL activation in the dentate gyrus Reduced canonical but increased non-canonical Wnt signaling
|
(85–92) |
| SFRP4-/-
|
Results in high total area and greater trabecularization. Does not lead to altered serum or urine phosphate levels. Alters body size, food intake and energy expenditure in obese mice. Increases trabecular bone formation and unusually thin cortical bone in mice. Decreases periosteal and endosteal bone formation in mice.
|
None. None. None. Wnt and BMP signaling. Repression of the Ror2/Jnk cascade in osteoclasts.
|
(25, 93–96) |
| SFRP5-/-
|
Not essential for axis formation or foregut morphogenesis in the mouse. Ameliorates mouse liver fibrosis. Regulates early lympho-hematopoiesis in the maternal bone marrow. diminishes cardiac inflammation and protects the heart from ischemia-reperfusion injury
|
None. Inhibition of Wnt5a/Fz2 signaling. Strongly block B-lymphopoiesis. Block the JNK activation by induction of Wnt5a in bone marrow derived macrophage
|
(97–100) |
| SFRP1-/-/SFRP2-/-
|
Regulates anteroposterior axis elongation and somite segmentation during mouse embryogenesis Requires for normal male sexual development. Regulates retinal neurogenesis. Requires for maintenance in lens epithelial cells
|
Alter oscillations of Notch signaling. Disrupted non-canonical Wnt signaling. Act as negative modulators of ADAM10. Wnt/β-catenin signaling.
|
(101–104) |
| SFRP2-/-/SFRP4-/-
|
Negatively regulates ovarian follicle development.
|
Wnt signaling pathway in ovarian follicle development.
|
(105) |
| SFRP1-/-/SFRP2-/- /SFRP5-/-
|
Regulates early Trunk Formation in Mouse.
|
Canonical and non-canonical pathways
|
(106) |
