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Biomarker characteristics.
| Biomarkers | MS vs. control | RRMS vs. SPMS | ||||
|---|---|---|---|---|---|---|
| Cut-off point* (ng/mL) | Sensitivity (%) | Specificity (%) | Cut-off point* (ng/mL) | Sensitivity (%) | Specificity (%) | |
| CSF SST | 2.0 | 97.5% | 92.5% | 0.4 | 58.8% | 65.2% |
| Serum SST | 12.3 | 37.5% | 82.5% | 12.1 | 47.1% | 69.6% |
| CSF IGFBP7 | 13.8 | 90% | 87.5% | 17.2 | 58.8% | 78.3% |
| Serum IGFBP7 | 3.7 | 80% | 67.5% | 4.3 | 76.5% | 69.6% |
*Cut-off point=maximum of (sensitivity + specificity -1).
