Glucose tolerance, fasting plasma insulin, insulin resistance and fasting plasma IGF-1 levels in female TejJ89, TejJ48 and TejJ114 mice under Ad libitum and 40% caloric restriction (CR). (A) Glucose tolerance (denoted by area under the curve (AUC) following a glucose injection, where n = 11–15 per group), (B) Fasting blood glucose (where n = 11–20 per group, (C) Fed blood glucose (where n = 11–12 per group), (D) Fasting plasma insulin levels (where n = 5–7 per group), (E) Insulin resistance as determined by HOMA2 (where n = 5–7 per group), (F) Fasting plasma IGF-1 levels (where n = 5–7 per group). Values are mean ± standard error of the mean (SEM). Treatment effects are denoted by *p < 0.05; **p < 0.01; ***p < 0.001 and strain effects are denoted by sp < 0.05; sssp<0.001.