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Study pipeline. T1-weighted (T1w) and fluid attenuated inversion recovery (FLAIR) images were used to quantify the volumes of hippocampal subfields and to segment whole-brain lesions in multiple sclerosis patients and healthy subjects. Subsequently, from volumes of hippocampal subfields, single-subject connectivity matrices were constructed. Comparisons between females and males in hippocampal connectivity and hippocampal lesion volumes were evaluated.
