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. 2021 Aug 23;3(3):fcab198. doi: 10.1093/braincomms/fcab198

Figure 5.

Figure 5

Sex-specific relationship between hippocampal subfield volumes and cognitive and memory performance. (A) Significant associations between composite cognitive performance and subfield volumes in female (cornu ammonis 1/3/4—CA1/CA3/CA4, granule cell layer of dentate gyrus—GCDG, hippocampus-amygdala transition area—HATA, molecular layer) and male (CA1, molecular layer) MS patients. The slopes are significantly different between the female and male MS patients for the relation between cognitive performance and volumes of CA3 (F = 3.44, P = 0.03), CA4 (F = 3.20, P = 0.04), CCDG (F = 3.42, P = 0.03) and HATA (F = 3.55, P = 0.02). (B) Significant associations between composite memory performance and subfield volumes in female (presubiculum, cornu ammonis 3/4—CA3/CA4, granule cell layer of dentate gyrus—GCDG, fimbria) and male (hippocampus-amygdala transition area—HATA) MS patients. The slopes are significantly different between the female and male MS patients for the relation between memory performance and volumes of presubiculum (F = 3.64, P = 0.03), CA3 (F = 4.31, P = 0.02), CA4 (F = 4.99, P = 0.01), CCDG (F = 3.91, P = 0.02) and fimbria (F = 4.03, P = 0.02).