Name	Grade	Attribution
Lung infection	3	Unrelated
Pneumonia	3	Unrelated
Pneumothorax	3	Unrelated
Pneumothorax	3	Unrelated
Compression fracture	3	Unrelated
Pneumonia	3	Unrelated
Gastroenteritis	3	Unrelated
Viral infection	3	Unrelated
Pancreatitis	2	Unrelated
Rectal hemorrhage	3	Unrelated
Deep vein thrombosis	3	Unrelated
Bile duct obstruction	3	Unrelated
Abdominal pain	3	Possible
Aspartate aminotransferase increased	3	Possible
Alanine aminotransferase increased	3	Possible
Sepsis	4	Unlikely
Sepsis	3	Unlikely
Sepsis	4	Unlikely
Diverticulitis	3	Unrelated
Fecaloma	3	Unrelated
Back pain	3	Unrelated
Dehydration	3	Unrelated
Urinary tract infection	2	Unrelated
Dyspnea	5	Unrelated

Serious Adverse Events Legend

The two SAEs of pneumonia and two SAEs of pneumothorax all occurred in the same patient.

The SAEs of viral infection and pancreatitis occurred >30 days after the last dose of study drug.

The three SAEs of sepsis all occurred in the same patient.