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. 2021 Aug 20;12:699746. doi: 10.3389/fimmu.2021.699746

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Copyright © 2021 Razeghian, Suksatan, Sulaiman Rahman, Bokov, Abdelbasset, Hassanzadeh, Marofi, Yazdanifar and Jarahian

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The recognized receptors for TRAIL. TRAIL connects with two agonistic receptors, termed TRAIL-R1 (DR4) and TRAIL-R2 (DR5), and three antagonistic receptors, termed TRAIL-R3 (DcR1), TRAIL-R4 (DcR2) as well as a soluble receptor, known as osteoprotegerin (OPG). TRAIL, Tumor necrosis factor-related apoptosis inducing ligand.