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. 2021 Jun 3;151(9):2590–2600. doi: 10.1093/jn/nxab156

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© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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Direct and indirect relations between iron regulatory hormones and SF in umbilical cord blood in neonates born to women carrying multiple fetuses and teens carrying singletons. Mediation models were utilized to assess direct (consistent lines) and indirect (dashed line) associations between biomarkers in umbilical cord blood. (A) Direct relations (consistent line) between EPO as the independent variable and ERFE or hepcidin as the dependent variable as well as the direct relation between ERFE as the independent variable and hepcidin as the dependent variable; also, the indirect relation between EPO and hepcidin through ERFE (dashed line). (B) Direct relations (consistent line) between ERFE as the independent variable and SF or hepcidin as the dependent variable as well as the direct relation between hepcidin as the independent variable and SF as the dependent variable; also, the indirect relation between ERFE and SF through hepcidin (dashed line). Bolded coefficients and P values indicate significant effects (P < 0.05). EPO, erythropoietin; ERFE, erythroferrone; SF, serum ferritin.