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. 2021 Sep 4;11:170. doi: 10.1186/s13578-021-00682-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — LC3 expression is inversely correlated with that of Snail and prognosis in TNBC. a Expression of LC3 and Snail in 13 TNBC tissue samples is detected using mmunohistochemistry (mean ± SD, magnification × 10, scale bars: 50 μm, *P < 0.05). b Expression of LC3, Snail, and E-cadherin in 13 TNBC tissue samples is detected using multicolor immune fluorescence (mean ± SD, magnification × 20, scale bars: 50 μm, magnification × 69.1, scale bars: 10 μm, *P < 0.05). c, d The prognostic values of the mRNA expression ratio of Snail/LC3 in TNBC patients are analyzed (Kaplan–Meier plotter). A higher Snail/LC3 mRNA expression ratio is associated with poorer distance metastasis free survival (P = 0.015) in the Gene-Chip Datasets (c) and poorer disease specific survival (P = 0.04), disease free interval (P = 0.029) and progression free interval (P = 0.027) in TCGA RNA-Seq datasets (d). The top quartile was used as the cutoff value