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. 2021 Sep 3;21:989. doi: 10.1186/s12885-021-08729-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Circulating miR-1290 is a potential diagnostic biomarker in gastrointestinal tumors. a Serum miR-1290 expression levels in PC patients (n = 46) and healthy controls (n = 50) were analyzed by RT-qPCR. b Serum miR-1290 expression levels in CRC patients (n = 50) and healthy controls (n = 50) were analyzed by RT-qPCR. c serum miR-1290 expression levels in GC patients (n = 50) and healthy controls (n = 50) were analyzed by RT-qPCR. d Circulating miR-1290 yielded AUC value of 0.8857 with 67.4% sensitivity and 90.0% specificity in distinguishing PC patients from healthy controls (p < 0.001). e Circulating miR-1290 yielded AUC value of 0.7852 with 48.0% sensitivity and 90.0% specificity in distinguishing CRC patients from healthy controls (p < 0.001). f Circulating miR-1290 yielded AUC value of 0.6576 with 34.0% sensitivity and 90.0% specificity in distinguishing GC patients from healthy controls (p < 0.001). g Sensitivity and specificity of circulating miR-1290 combined with CA199 were 80.4 and 90.0% with the AUC value of 0.9626 in PC (p < 0.0001). h Sensitivity and specificity of circulating miR-1290 combined with CEA were 58.0 and 90.0% with the AUC value of 0.8348 in CRC (p < 0.0001). i Sensitivity and specificity of circulating miR-1290 combined with CA211 were 38.0 and 90.0% with the AUC value of 0.7788 in PC (p < 0.0001). * p < 0.05, ** p < 0.01