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. 2021 Sep 3;21:989. doi: 10.1186/s12885-021-08729-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Circulating miR-1290 is a promising biomarker for disease surveillance. a The tumor growth curve of different groups. Compared to the saline group, tumor growth in 5-FU-treated group was significantly inhibited. b Images of all tumors from nude mouse. Tumors in 5-FU group were significantly smaller than those in saline group. c Comparison of tumor weights between saline group and 5-FU group. Tumors in the saline group were heavier than those in the 5-FU group. d H&E staining of tumors of saline and 5-FU group. The 5-FU group exhibited a large degree of cell apoptosis and necrosis. e The fluctuation of circulating miR-1290 during disease progression and drug treatment in the xenograft mouse model. f Changes of serum miR-1290 levels in CRC patients after surgery were determined by RT-qPCR (n = 10). * p < 0.05, ** p < 0.01, *** p < 0.001