Table 2.
Estimated associations with the underlying cognitive ability and functional dependency level at baseline (n = 297), COGICARE study
| Cognitive ability at baseline | Functional dependency at baseline | |||||
|---|---|---|---|---|---|---|
| Coefficient* | 95% confidence interval | Coefficient* | 95% confidence interval | |||
| Clinical stage by education level | ||||||
| Higher than primary school | ||||||
| CN | 0 | - | 0 | - | ||
| MCI | − 0.882 | − 1.284 | − 0.480 | 0.171 | − 0.275 | 0.617 |
| AD | − 2.878 | − 3.419 | − 2.337 | 1.974 | 1.415 | 2.532 |
| Lower or equal to primary school | ||||||
| CN | − 0.868 | − 1.308 | − 0.429 | 0.188 | − 0.417 | 0.793 |
| MCI | − 1.531 | − 2.044 | − 1.018 | 0.089 | − 0.412 | 0.591 |
| AD | − 3.572 | − 4.219 | − 2.926 | 2.811 | 2.105 | 3.518 |
| Age at baseline | ||||||
| ≤ 79.1 | 0 | - | 0 | - | ||
| 79.1–82.0 | − 0.284 | − 0.680 | 0.113 | 0.069 | − 0.396 | 0.534 |
| 82.0–84.5 | − 0.461 | − 0.870 | − 0.053 | 0.304 | − 0.167 | 0.775 |
| 84.5–87.7 | − 0.288 | − 0.691 | 0.116 | 0.284 | − 0.200 | 0.767 |
| > 87.7 | − 0.754 | − 1.146 | − 0.362 | 1.028 | 0.508 | 1.549 |
| APOE ε4 carrier | ||||||
| No | ||||||
| Yes | − 0.010 | − 0.351 | 0.331 | − 0.355 | − 0.741 | 0.031 |
| Sex | ||||||
| Male | ||||||
| Female | − 0.016 | − 0.270 | 0.238 | 0.316 | − 0.017 | 0.650 |
*One-unit difference corresponds to the standard deviation of the dimension at baseline in the category reference (CN men with a higher educational level and less than 79.6 years old at baseline)