Table 2.

Clinical presentation, CSF findings, SFTS-DNA testing and imaging findings in patients with SFTS-associated encephalopathy/encephalitis who underwent CSF testing (n = 7)

Case no.	Age /sex	Days to neurological presentation	Neurological presentation	CSF findings								Blood SFTSV- RNA load (copies/ml)	Brain CT	Brain MRI	Co-infection	Outcome
				WBC (*106/L)	Neutrophils (%)	Lymphocyte (%)	Protein (mg/L)	Glucose (mmol/L)	Chlorine (mmol/L)	IgG (mg/L)	SFTSV-RNA load (copies/ml)
			Normal range	0–8	0–6	40–80	140–450	2.5–4.5	120–132	4.8–58.6	Negative	Negative
1	61/M	6th day	Unconsciousness, seizure	9.0	35	65	736	5.14	130.9	187	103/L	106/L	Lacunar infarction	Chronic hypoxia changes in white matter	IPA	Died
2	71/M	4th day	Unconsciousness	6.0	66.6	33.4	976	2.41	123	148	103/L	104/L	Lacunar infarction	Chronic hypoxia changes in white matter	IPA, bacteremia	Died
3	71/F	4th day	Altered mental status, disorientation	5.0	20	80	469	3.22	130	NA	103/L	106/L	Lacunar infarction	NA	IPA	Died
4	64/M	4th day	Unconsciousness, seizure	1.0	0	100	572	3.97	126.2	53.1	103/L	106/L	Lacunar infarction	NA	Bacteremia	Died
5	45/M	7th day	Headache, altered mental status	1.0	0	100	542	3.26	133	29.5	Negative	106/L	Lacunar infarction	Chronic hypoxia changes in white matter	No	Survived
6	76/F	3rd day	Unconsciousness	0	0	0	914	5.35	135.3	61	Negative	108/L	NA	NA	No	Died
7	28/M	5th day	Headache, altered mental status	50	36	54	1226	1.33	129	NA	Negative	108/L	ICH	Multiple abnormal signal shadows	IPA	Died
8	61/F	4th day	Headache, altered mental status	3	33.3	66.7	498	9.77	119	NA	NA	106/L	Normal	NA	IPA, bacteremia	Died
9	49/M	6th day	Headache, altered mental status	4	25	75	416	4.02	126	NA	NA	106/L	NA	NA	IPA, bacteremia	Died
10	75/M	4th day	Headache, altered mental status	7	50	50	904	6.16	138	NA	NA	104/L	Lacunar infarction	NA	IPA, bacteremia	Died

SFTS severe fever with thrombocytopenia syndrome, CSF cerebrospinal fluid, WBC white blood cell, ICH intracranial haemorrhage, NA not available