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. 2021 Aug 13;11:684351. doi: 10.3389/fonc.2021.684351

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Copyright © 2021 Kui, Kong, Yang, Pan, Xu, Wang, Chen, Wei, Zhou, Yang, Wu, Mastan, Liu and Miao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KEGG pathways in three candidate drugs and group 3. (A–C) Three TCM (R. communis L., E. cochinchinensis Lour., B. fruticosa) which were enriched on all five pathways: TNF signaling pathway, IL−17 signaling pathway, NF-kappa B signaling pathway, Transcriptional misregulation in cancer, and MAPK signaling pathway; (D) group 3 includes three important pathways: IL−17 signaling pathway and TNF signaling pathway participated in the pro-inflammatory process; Transcriptional misregulation in cancer is important for cancer metastasis process.