Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 18;9:717903. doi: 10.3389/fcell.2021.717903

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Shao, Gu, Zhou, Wang, Li, Deng and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Occurrence and development of tissue Tregs. Derived from the normal thymus, Tregs have two different ways to develop. In the thymus, CD4⁺ thymocytes turn into tTregs by TCRs. In periphery, Tregs occur with IL-2 and TGF-β. These Tregs stay in SLO, and then migrate into tissues once being stimulated. Tregs, regulatory T cells; tTregs, thymic Tregs; pTregs, peripheral Tregs; TCR, T cell receptors; Th1, T-helper 1; Th2, T-helper 2; Th17, T-helper 17; IFN-γ, interferon-gamma; TGF-β, transforming growth factor beta; IL-12, interleukin-12; IL-4, interleukin-4; IL-6, interleukin-6; IL-2, interleukin-2; IL-23, interleukin-23; CCL, chemokine (C-C motif) ligand.