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. 2021 Aug 13;12:691811. doi: 10.3389/fimmu.2021.691811

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Copyright © 2021 Zhang, Zhang, Wang, Dai, Zhang, Cheng and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distinct genomic profiles associated with the TME-score. (A) GISTIC 2.0 amplifications and deletions in gliomas with high and low TME-scores. Chromosomal locations of peaks of significantly recurring focal amplifications (red) and deletions (blue) are presented. (B) Differential somatic mutations were detected in gliomas with high TME-score. (C) Differential somatic mutations were detected in gliomas with low TME-score. (D) Subgroup analyses estimating the clinical prognostic value between low/high TME-score groups in independent glioma datasets.