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. 2021 Aug 13;12:691811. doi: 10.3389/fimmu.2021.691811

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Copyright © 2021 Zhang, Zhang, Wang, Dai, Zhang, Cheng and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential immune escape mechanisms related to TME-score. (A) Characterization of the immune suppressive signatures associated with TME-scores in TCGA. (B) Fraction of m6A signature genes in TME-score in TCGA. (C) APM score in high and low TME-score. (D) CTA score in high and low TME-score. (E) SNV neoantigens in high and low TME-score. (F) Nonsilent mutation rate in high and low TME-score. (G) Number of segments in high and low TME-score. (H) Aneuploidy score in high and low TME-score. (I) Leukocyte fraction in high and low TME-score. (J) Stromal fraction in high and low TME-score. (K) TGF-beta response in high and low TME-score. NS, Not Statistically Significant; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.