TABLE 1.

TFEB serves as a potential therapeutic target for human diseases.

Diseases		TFEB as a disease inductor	TFEB as a treatment target
Tumors	Pancreatic cancer	Increased TFEB promotes autophagy to meet the metabolic needs for growth and metastasis of tumor cells	Inhibition of TFEB enhances the sensitivity to chemotherapy
	Lung cancer	Upregulated TFEB enhances the release of cathepsins to facilitate metastasis; Increased TFEB develops resistance to chemotherapy	Down-regulation of TFEB augments the sensitivity to chemotherapy
	Breast cancer	Activated DNA repair inhibits apoptosis of tumor cells	Inhibition of TFEB in breast cancer cells promotes tumor cell death; upregulated TFEB in macrophages enhances the inhibition of tumor progression
	TFEB RCC	Translocation or rearrangement of TFEB gene leads to nuclear TFEB overexpression	−
Inflammatory diseases	Atherosclerosis	−	Antioxidation in endothelial cells; the enhancement of lysosomal function in macrophages; lipophagy promotion in vascular smooth muscle cells.
	Sepsis	−	Autophagy restoration by upregulation of TFEB
	Osteoarthritis	Inhibited expression and nuclear import of TFEB	Autophagy promotion by TFEB overexpression
Neurodege nerative diseases	Parkinson disease	Cytoplasmic retention of TFEB leads to decreased lysosomal function and excessive α-synuclein production	Activation of TFEB reverses lysosomal dysfunction and reduces oxidative stress
	Alzheimer disease	−	Elevated TFEB expression or deacetylation of TFEB improves the degradation of tau
	Huntington disease	Reduced TFEB level and target genes expression	Activation or overexpression of TFEB increases the clearance of HTT