Table 2.
Platelet counts among the three groups.
| Eltrombopag (A) | rhTPO (B) | Control (C) | P value | ||||
|---|---|---|---|---|---|---|---|
| Overalla | A vs C | B vs C | A vs B | ||||
| Day 0, N | 51 | 50 | 52 | ||||
| Platelet count (×109/L) | 23.96 ± 14.15 | 23.92 ± 12.45 | 24.15 ± 7.47 | .711 | / | / | / |
| Day 3, N | 51 | 50 | 52 | ||||
| Platelet count (×109/L) | 25.24 ± 11.12 | 25.94 ± 10.08 | 25.21 ± 5.70 | .613 | / | / | / |
| Day 5, N | 51 | 50 | 52 | ||||
| Platelet count (×109/L) | 44.24 ± 17.51 | 48.92 ± 32.46 | 33.73 ± 24.62 | .001 | .003 | .005 | 1.000 |
| Day 7, N | 46 | 45 | 50 | ||||
| Platelet count (×109/L) | 67.30 ± 29.90 | 82.11 ± 33.37 | 41.58 ± 21.27 | .000 | .000 | .000 | .187 |
| Day 10, N | 44 | 44 | 45 | ||||
| Platelet count (×109/L)b | 130.73 ± 70.57 | 147.02 ± 68.47 | 75.67 ± 40.40 | .000 | .000 | .000 | .598 |
| The lowest platelet count (×109/L)b | 15.94 ± 9.09 | 18.28 ± 15.59 | 11.37 ± 7.66 | .004 | .041 | .005 | 1.000 |
| P1c | 0.614 | 0.375 | 0.419 | ||||
| P2d | 0.000 | 0.000 | 0.113 | / | / | / | |
| P3e | 0.000 | 0.000 | 0.000 | / | / | / | |
| P4f | 0.000 | 0.000 | 0.000 | / | / | / | |
Data are mean ± SD.
a
P value compares platelet counts among the three groups.
b
Defined as the lowest platelet count observed after treatment initiation (or after enrolment for patients of the control group).
c
P value compares platelet counts between Day 0 and Day 3.
d
P value compares platelet counts between Day 0 and Day 5.
e
P value compares platelet counts between Day 0 and Day 7.
f
P value compares platelet counts between Day 0 and Day 10.