Table 1.
Comparison of pre-, intra-, and short-term post-operative data with sarcopenic status in whole cohort.
| All study participants (N = 101) | Sarcopenic (n = 64) | Non-sarcopenic (n = 37) | Pa | |
|---|---|---|---|---|
| Patient characteristics | ||||
| Female (%) | 47 (47) | 36 (56) | 11 (30) | 0.01* |
| Age at imaging, median (IQR), mo | 35 (27, 60) | 32 (26, 57) | 36 (28, 64) | 0.56 |
| Age at diagnosis, median (IQR), mo | 26 (14, 45) | 26 (16, 46) | 27 (12, 46) | 0.85 |
| Weight-for-age, mean (SD), z | −0.37 (1.11) | −0.80 (1.02) | 0.36 (0.85) | <0.001* |
| Height-for-age, mean (SD), z | −0.20 (1.25) | −0.58 (1.24) | 0.44 (1.01) | <0.001* |
| BMI, mean (SD), z | −0.36 (1.23) | −0.63 (1.23) | 0.11 (1.04) | 0.003* |
| Disease characteristics | ||||
| Histology, no. (%) | n/ab | |||
| Ganglioneuroma | 10 (10) | 1 (2) | 9 (24) | |
| Ganglioneuroblastoma | ||||
| Intermixed | 5 (5) | 4 (6) | 1 (3) | |
| Nodular | 7 (7) | 4 (6) | 3 (8) | |
| Neuroblastoma, differentiating | 23 (23) | 17 (27) | 6 (16) | |
| Neuroblastoma, poorly differentiated | 11 (11) | 7 (11) | 4 (11) | |
| Neuroblastoma, undifferentiated | 7 (7) | 4 (6) | 3 (8) | |
| More than one classification | 5 (5) | 3 (5) | 2 (5) | |
| Adrenal gland location, no. (%) | 56 (55) | 36 (56) | 20 (54) | 0.84 |
| INSS 4, no. (%) | 51 (50) | 37 (58) | 14 (38) | 0.07 |
| MYCN+, no. (%) | 21 (21) N = 100 | 17 (27) n = 64 | 4 (11) n= 36 | 0.08 |
| Cancer treatment | ||||
| Pre-operative chemotherapy, no. (%) | N = 63 | n = 40 | n = 23 | 0.433 |
| No chemotherapy | 17 (30) | 9 (22.5) | 8 (35) | |
| NB2004 medium-risk groupc | 12 (19) | 8 (20) | 4 (17) | |
| NB2004 high-risk groupc | 34 (54) | 23 (57.5) | 11 (48) | |
| Short-term outcome | ||||
| Time in hospital after surgery, median (IQR), d | 12 (9, 23) | 14 (10, 24) | 11 (8, 21) | 0.22 |
| Time in ICU after surgery, median (IQR), d | 4 (2, 6) N = 99 | 5 (2, 6) n = 64 | 3 (1, 6) n = 35 | 0.13 |
| Sepsis | 3 (3) | 2 (3) | 1 (3) | >0.99 |
*
Represents a significant result with P <0.05.
a
P-value for comparison between sarcopenic and non-sarcopenic.
b
Statistic cannot be completed due to small number of patients per group.
c
According to GPOH recommendations (29).
BM I, body mass index; d, days; ICU, intensive care unit; INSS, international Neuroblastoma Staging System; IQR, interquartile range; mo, months; SD, standard deviation: z, z-score.