Table 1.
Cohorts included in the meta-analysis
| Stage | Cohort | n | PH (%) | Location | Array |
|---|---|---|---|---|---|
| Discovery | GENISIS | 1062 | 52 (4.9) | Spain | HumanCore ExomeChip |
| GODS | 234 | 14 (6) | Spain | HumanCore ExomeChip | |
| GRECOS | 28 | 5 (17.9) | Spain | HumanCore ExomeChip | |
| Overall | 1324 | 71 (5.4) | – | – | |
| Replicationa | Geno-tPAb | 157 | 36 (22.9) | Spain | Omni 1.5 M |
| BASICMARb | 91 | 8 (8.8) | Spain | Omni 5 M | |
| LSGSb | 45 | 8 (17.8) | Belgium | Omni 5 M | |
| HELSINKI 2000c | 164 | 12 (7.3) | Finland | HumanCore ExomeChip | |
| GENISISc | 70 | 2 (2.9) | Finland | HumanCore ExomeChip | |
| GENISIS | 53 | 4 (7.5) | Poland | HumanCore ExomeChip | |
| Overall | 580 | 70 (12.1) | – | – | |
| Overall | – | 1904 | 141 (7.4) | – | – |
BASICMAR = Base de Datos de Ictus del Hospital del Mar (Hospital del Mar Stroke Database); GENISIS = Genetics of Early Neurological Instability after Ischaemic Stroke study; Geno-PA = Genetic study in ischaemic stroke patients treated with tPA; GODS = Genetic contribution to Functional Outcome and Disability after Stroke study; GRECOS = Genotyping Recurrence Risk of Stroke; HELSINKI 2000 = Helsinki 2000 Ischaemic Stroke Genetics Study; LSGS = Leuven Stroke Genetics Study; PH = parenchymal haematoma.
a
Contributing cohorts were not analysed by ancestry stratum due to the limited samples available.
b,c
In the replication stage, in these cohorts, groups were pooled and imputed based on genotyping array.