Table 4.

Independent leading SNPs and the most significant associations with parenchymal haematoma in the meta-analysis

SNP	CHR	Position (bp)	Location	Gene	EA/NEA	No. variants	EAF	Stage	OR (95% CI)	P
rs77557904	2	1047076	Intronic	SNTG2	G/C	1	0.06	Meta-analysis	3.82 (2.19–6.68)	2.43 × 10−6
								Discovery	6.56 (3.10–13.89)	8.62 × 10−7
								Replication	2.01 (0.88–4.59)	0.1
rs112541215	2	218916291	Intronic	RUFY4	A/T	1	0.08	Meta-analysis	3.01 (1.88–4.84)	4.79 × 10−6§
								Discovery	4.67 (2.43–8.96)	3.76 × 10−6
								Replication	1.90 (0.96–3.74)	0.07
rs1962779	7	83837734	Intronic	SEMA3A	C/G	40	0.19	Meta-analysis	2.43 (1.76–3.37)	7.85 × 10−8§
								Discovery	2.94 (1.87–4.61)	2.77 × 10−6
								Replication	2.00 (1.26–3.18)	3.34 × 10−3
rs4356265	11	117301818	Intronic	DSCAML1	T/C	1	0.11	Meta-analysis	2.75 (1.83–4.15)	1.33 × 10−6§
								Discovery	3.92 (2.23–6.88)	1.89 × 10−6
								Replication	1.87 (1.03–3.38)	0.04
rs564865745	12	41626444	Intronic	PDZRN4	G/A	57	0.05	Meta-analysis	4.23 (2.37–7.54)	1.03 × 10−6
								Discovery	9.89 (4.20–23.28)	1.56 × 10−7
								Replication	2.12 (0.97–4.62)	0.06
rs76484331	20	62422504	Intronic	ZBTB46	A/C	43	0.1	Meta-analysis	5.84 (3.16–10.76)	1.61 × 10−8*
								Discovery	11.31 (4.82–26.55)	2.49 × 10−8*
								Replication	2.97 (1.24–7.09)	0.01

CHR = chromosome; EA = effect allele; EAF = effect allele frequency; No. variants = number of variants reaching P > 1 × 10⁻⁵; NEA = non-effect allele. Only independent SNPs (r² < 0.1, within a 1 Mb window) with a P-value < 1 × 10⁻⁵ are shown. Alleles and chromosomal positions were identified on the basis of the 1000 Genomes Phase 3 Project. Location was described following the ANNOVAR system.

*P-value < 5 × 10⁻⁸.

^§Heterogeneity P-value > 0.05.