Table 1.
In vitro Activity of Imipenem/Relebactam and Imipenem Against P. Aeruginosa and A. Baumannii Collected in China from 2015 to 2018
| Organism/Antimicrobial Agent | MIC (mg/L) | MIC Interpretation | ||||
|---|---|---|---|---|---|---|
| MIC50 | MIC90 | MIC Range | Susceptible Rate (%) | Intermediate Rate (%) | Resistant Rate (%) | |
| P. aeruginosa (N = 1886) | ||||||
| Imipenem/relebactam | 0.5 | 8 | < 0.6 to > 32 | 84.2 | 5.0 | 10.8 |
| Imipenem | 2 | 32 | < 0.12 to > 32 | 55.7 | 6.2 | 38.1 |
| Imipenem-non-susceptible P. aeruginosa (N = 835) | ||||||
| Imipenem/relebactam | 2 | > 32 | 0.25 to > 32 | 64.4 | 11.1 | 24.4 |
| Imipenem | 16 | > 32 | 4 to > 32 | 0.0 | 13.9 | 86.1 |
| MDR P. aeruginosa (N = 835) | ||||||
| Imipenem/relebactam | 2 | > 32 | < 0.06 to > 32 | 65.8 | 10.2 | 24.1 |
| Imipenem | 16 | > 32 | 0.25 to > 32 | 25.2 | 6.7 | 68.1 |
| A. baumannii (N = 1889) | ||||||
| Imipenem/relebactam | 32 | > 32 | < 0.06 to > 32 | 22.2 | 0.6 | 77.2 |
| Imipenem | 32 | > 32 | < 0.12 to > 32 | 21.0 | 0.5 | 78.6 |
| Imipenem-non-susceptible A. baumannii (N = 1493) | ||||||
| Imipenem/relebactam | 32 | > 32 | 0.25 to > 32 | 1.8 | 0.7 | 97.5 |
| Imipenem | 32 | > 32 | 4 to > 32 | 0.0 | 0.6 | 99.4 |
| MDR A. baumannii (N = 1547) | ||||||
| Imipenem/relebactam | 32 | > 32 | < 0.06 to >32 | 5.3 | 0.7 | 94.1 |
| Imipenem | 32 | > 32 | 0.25 to > 32 | 4.0 | 0.4 | 95.6 |
Abbreviations: MIC, minimum inhibitory concentrations; MDR, multidrug resistance.