Table 2.
In vitro Activity of Imipenem/Relebactam and Imipenem Against P. Aeruginosa Isolates from ICUs and Non-ICU Wards
| Organism/Antimicrobial Agent | ICU Origin (IAIs + UTIs + RTIs) | Non-ICU Origin (IAIs + UTIs + RTIs) | ||||||
|---|---|---|---|---|---|---|---|---|
| N | S% | R% | MIC90 | N | S% | R% | MIC90 | |
| P. aeruginosa | ||||||||
| Imipenem/relebactam | 441 | 345 (78.2) | 72 (16.3) | 32 | 1445 | 1243 (86.0) | 132 (9.1) | 4 |
| Imipenem | 441 | 209 (47.4) | 208 (47.2) | > 32 | 1445 | 842 (58.3) | 511 (35.4) | 32 |
| Imipenem-non-susceptible P. aeruginosa | ||||||||
| Imipenem/relebactam | 232 | 136 (58.6) | 72 (31.0) | > 32 | 603 | 402 (66.7) | 132 (21.9) | 32 |
| Imipenem | 232 | 0 (0.0) | 208 (89.7) | > 32 | 603 | 0 (0.0) | 511 (84.7) | > 32 |
| MDR P. aeruginosa | ||||||||
| Imipenem/relebactam | 229 | 134 (58.5) | 72 (31.4) | > 32 | 606 | 415 (68.5) | 129 (21.3) | 32 |
| Imipenem | 229 | 48 (21.0) | 169 (73.8) | > 32 | 606 | 162 (26.7) | 400 (66.0) | > 32 |
Abbreviations: IAIs, intra-abdominal infections; ICU, intensive care unit; MDR, multidrug-resistance; MIC, minimum inhibitory concentrations; N, number; R, resistant rate; RTIs, respiratory tract infections; S, susceptible rate; UTIs, urinary tract infections.