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. 2021 Mar 8;113(9):1212–1220. doi: 10.1093/jnci/djab029

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Flowchart. ^aOne case with MLH1 promoter hypermethylation in the tumor carried a germline MLH1 variant. ^bInsufficient material for assay. EC = endometrial cancer; LS = Lynch syndrome; Methylation (+) = MLH1 promoter hypermethylation; Methylation (−) = no MLH1 promoter hypermethylation; MMR = mismatch repair; MMRd = mismatch repair deficient; MMRp = mismatch repair proficient; MSI = microsatellite instability; NGS = next-generation sequencing.