Figure 2.

Lifetime absolute risk of breast cancer by polygenic risk score (PRS) category in African American women. Lifetime absolute risk of developing breast cancer for the 313-variant PRS (PRS₃₁₃) in African American women for overall breast cancer (A), estrogen receptor (ER)-positive breast cancer (B) and ER-negative breast cancer (C) and in European-ancestry women for overall breast cancer (D), ER-positive breast cancer (E), and ER-negative breast cancer (F). The x-axis represents age and the y-axis is the absolute risk of breast cancer by a given age. The different colored lines represent the corresponding PRS strata. See Methods for details about the calculation of absolute risks.