Table 1.

Association between PRS and overall breast cancer risk in women of African ancestry

PRS and AUCa	Controls, No.	PRS179			PRS313
		Cases, No.	OR (95% CI)b	P c	Cases, No.	OR (95% CI)b	P c
PRS category, %
<1	106	58	0.62 (0.44 to 0.89)	.009	60	0.63 (0.44 to 0.89)	.009
1-5	406	248	0.70 (0.58 to 0.84)	1.43 × 10−4	235	0.70 (0.58 to 0.85)	2.29 × 10−4
5-10	508	306	0.67 (0.56 to 0.79)	2.25 × 10−6	309	0.72 (0.61 to 0.85)	9.51 × 10−5
10-20	1020	687	0.74 (0.65 to 0.84)	2.84 × 10−6	681	0.74 (0.65 to 0.84)	3.52 × 10−6
20-40	2038	1598	0.89 (0.81 to 0.99)	.03	1560	0.84 (0.76 to 0.93)	6.92 × 10−4
40-60	2038	1808	1.00 (Referent)	—	1802	1.00 (Referent)	—
60-80	2038	2033	1.10 (1.00 to 1.22)	.045	1952	1.03 (0.94 to 1.14)	.50
80-90	1019	1093	1.17 (1.04 to 1.32)	.008	1197	1.29 (1.15 to 1.45)	1.22 × 10−5
90-95	508	645	1.42 (1.23 to 1.65)	1.80 × 10−6	643	1.38 (1.20 to 1.60)	1.28 × 10−5
95-99	406	593	1.60 (1.37 to 1.87)	2.15 × 10−9	602	1.61 (1.38 to 1.87)	1.32 × 10−9
>99	106	172	1.83 (1.39 to 2.40)	1.56 × 10−5	200	2.01 (1.53 to 2.63)	3.69 × 10−7
Continuous PRS per 1 SD	10 193	9241	1.26 (1.22 to 1.30)	2.59 × 10−45	9241	1.27 (1.23 to 1.31)	4.23 × 10−49
AUC			0.568 (0.56 to 0.576)	—		0.571(0.562 to 0.579)	—

^aAUCs were adjusted for study and the first 10 principal components. AUC = area under the receiver operating characteristic curve; CI = confidence interval; GBHS = Ghana Breast Health Study; OR = odds ratio; PRS = polygenic risk score.

^bOdds ratios were estimated using unconditional logistic regression model, adjusting for age, study, and the first 10 principal components in each consortium and in the GBHS and then combined using a fixed-effect meta-analysis with inverse variance weights.

^cTwo-sided P values were Wald P value from fixed-effect meta-analysis.