Table 3.
Observed and expected EC rates in BRCA1/2 mutation carriers compared with the Dutch country-specific incidence rates, according to attained age
| EC subgroup, age categories | BRCA1/2 carriers | Dutch population | SIR (95% CI) |
|---|---|---|---|
| Observed | Expected | ||
| All ECs | 58a | 20.53 | 2.83 (2.18 to 3.65) |
| 25-40 y | 4 | 0.41 | 9.84 (2.68 to 25.20) |
| 40-60 y | 25 | 10.0 | 2.50 (1.62 to 3.69) |
| 60-80 y | 28 | 9.56 | 2.93 (1.95 to 4.24) |
| Serous-like | 19 | 1.95 | 9.77 (6.23 to 15.31) |
| 25-40 y | 0 | 0.02 | 0.00 (0.00 to 149.82) |
| 40-60 y | 6 | 0.69 | 8.68 (3.19 to 18.90) |
| 60-80 y | 13 | 1.15 | 11.27 (5.99 to 19.27) |
a
One EC occurred after 80 years of age. Given the low number of person-years after 80 years of age, this age category is not presented in the table. CI = confidence interval; EC = endometrial cancer; SIR = standardized incidence ratio.