FIGURE 5.

METTL3 facilitates LIHC cells growth and metastasis via ASPM. SNU449 and Hepg3b cells were cotransfected with METTL3 shRNA plasmid and ASPM overexpression plasmid. (A) The expression level of ASPM was examined using Western blot and qPCR. The CCK‐8 (B) and colony formation (C) were used to analyze the proliferation rate. The transwell invasion (D) and wound scratch (E) experiments were performed to examine the migratory and invasive capacities. *p < 0.05, ***p < 0.001. Data represent at least three independent sets of experiment