TABLE 3.
Subgroup analysis of diagnostic accuracy of circRNAs in breast cancer
| Subgroups | CircRNAs | Sensitivity (95%CI) | Specificity (95%CI) | PLR (95%CI) | NLR (95%CI) | DOR (95%CI) | AUC (95%CI) | Heterogeneity I 2 test (%)/P het | Meta‐regression P‐value |
|---|---|---|---|---|---|---|---|---|---|
| Specimen | |||||||||
| Tissue | 17 | 0.73 (0.67–0.79) | 0.73 (0.65–0.81) | 2.8 (1.9–4.0) | 0.36 (0.27–0.49) | 8 (4–14) | 0.80 (0.76–0.83) | 84.9%/<0.01 | 0.620 |
| Plasma | 4 | 0.88 (0.72–0.95) | 0.60 (0.49–0.71) | 2.2 (1.7–2.9) | 0.20 (0.08–0.49) | 11 (4–31) | 0.67 (0.63–0.71) | 76.5%/<0.01 | |
| Case size | |||||||||
| ≥100 | 5 | 0.88 (0.73–0.95) | 0.85 (0.67–0.94) | 5.7 (2.5–13.0) | 0.15 (0.06–0.33) | 39 (11–136) | 0.93 (0.90–0.95) | 92.9%/<0.01 | 0.001 |
| <100 | 16 | 0.71 (0.65–0.75) | 0.66 (0.59–0.72) | 2.1 (1.7–2.5) | 0.45 (0.37–0.55) | 5 (3–7) | 0.74 (0.70–0.78) | 59.2%/<0.01 | |
| Altered expression | |||||||||
| Up‐regulated | 9 | 0.77 (0.64–0.87) | 0.68 (0.62–0.74) | 2.4 (2.1–2.8) | 0.33 (0.21–0.52) | 7 (4–12) | 0.74 (0.70–0.78) | 75.0%/<0.01 | 0.817 |
| Down‐regulated down‐regulated | 12 | 0.76 (0.67–0.83) | 0.74 (0.61–0.83) | 2.9 (1.8–4.8) | 0.33 (0.21–0.50) | 9 (4–22) | 0.81 (0.78–0.85) | 89.1%/<0.01 | |
| Overall | 21 | 0.77 (0.70–0.83) | 0.71 (0.63–0.78) | 2.6 (2, 0–3.5) | 0.33 (0.24–0.45) | 8 (5–14) | 0.80 (0.77–0.84) | 85.1%/<0.01 | |