TABLE 5.
The diagnostic efficiency of HGB, CA199, CA125, HE4, and the combined diagnosis model in endometriosis
| Parameters | AUC (95% CI) | Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | PPV (%) (95% CI) | NPV (%) (95% CI) | Cutoff value | Youden index | p‐value |
|---|---|---|---|---|---|---|---|---|
| HGB (g/L) | 0.748 (0.692–0.798) | 64.23 (55.6–72.2) | 76.64 (68.7–83.4) | 23.4 (18.0–29.8) | 95.1 (93.8–96.1) | 126 | 0.41 | <0.0001 |
| CA199 (U/ml) | 0.747 (0.692–0.798) | 60.58 (51.9–68.8) | 81.75 (74.3–87.8) | 26.9 (20.2–35.0) | 94.9 (93.7–95.9) | 16.05 | 0.42 | <0.0001 |
| CA125 (U/ml) | 0.867 (0.821–0.905) | 81.75 (74.3–87.8) | 84.67 (77.5–90.3) | 37.2 (28.4–47.0) | 97.7 (96.7–98.4) | 23.8 | 0.66 | <0.0001 |
| HE4 (pmol/L) | 0.631 (0.571–0.688) | 65.69 (57.1–73.6) | 55.47 (46.7–64.0) | 14.1 (11.6–17.0) | 93.6 (91.7–95.0) | 33.3 | 0.21 | 0.0001 |
| The combined diagnosis model | 0.900 (0.859–0.933) | 85.40 (78.4–90.8) | 78.83 (71.0–85.3) | 31.0 (24.4–38.4) | 98.0 (97.0–98.7) | −0.56 | 0.64 | <0.0001 |
Abbreviations: AUC, the area under the curve; CA, carbohydrate antigen; CI, confidence interval; HE4, human epididymis protein 4; HGB, hemoglobin; NPV, negative predictive value; PPV, positive predictive value.