TABLE 2.
Clinical performance of three immunoassays
Clinical diagnosis | Sensitivity | Specificity | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Positive | Negative | (95% CI) | (95% CI) | |||||||
D ≥ 14 | D < 14 | Healthy | Other | Total | D ≥ 14 | Total | Healthy | Other | ||
(n = 126) | (n = 47) | (n = 98) | (n = 53) | (n = 173) | (n = 126) | (n = 151) | (n = 98) | (n = 53) | ||
Abbott Quant | Pos | 123 | 43 | 1 | 0 | 96 | 97.6 | 99.3 | 99.0 | 100 |
Neg | 3 | 4 | 97 | 53 | (91.8–98.4) | (93.2–99.5) | (96.4–100.0) | (94.4–100.0) | (93.3–100.0) | |
DiaSorin TrimericS | Pos | 122 | 40 | 0 | 0 | 93.6 | 96.8 | 100 | 100 | 100 |
Neg | 4 | 7 | 98 | 53 | (88.9–96.8) | (92.1–99.1) | (97.6–100.0) | (96.3–100.0) | (93.3–100.0) | |
Roche S | Pos | 123 | 43 | 0 | 0 | 96 | 97.6 | 100 | 100 | 100 |
Neg | 3 | 4 | 98 | 53 | (91.9–98.4) | (93.2–99.5) | (97.6–100.0) | (96.3–100.0) | (93.0–100.0) | |
Genscript cPass | Pos | 123 | 41 | NT | NT | 94.8 | 97.6 | NT | NT | NT |
Neg | 3 | 6 | NT | NT | (90.4–97.6) | (93.2–99.5) | NT | NT | NT |
Abbreviations: Abbott Quant, Abbott SARS‐CoV‐2 IgG II Quant; D, days after onset of symptom; DiaSorin TrimericS, DiaSorin LIAISON SARS‐CoV‐2 TrimericS IgG; Genscript cPass, Genscript cPass SARS‐CoV‐2 Neutralization Antibody Detection Kit;NT, not tested; Other, other infection; Roche S, Roche Elecsys anti‐SARS‐CoV‐2 S.