TABLE 5.
AUC sensitivity, specificity, PPV, and NPV of tumor maker's combined assessment
| AUC | Sensitivity (%) | Specificity (%) | |
|---|---|---|---|
| CYFRA21‐1+ProGRP | 0.505 (0.454–0.555) | 44.03 (38.50–49.70) | 48.61 (36.70–60.70) |
| CYFRA21‐1+CEA | 0.502 (0.451–0.553) | 31.76 (26.70–37.20) | 58.33 (46.10–69.80) |
| CYFRA21‐1+NSE | 0.552 (0.501–0.602) | 24.53 (19.90–29.60) | 87.50 (77.60–94.10) |
| CYFRA21‐1+SCCA | 0.562 (0.511–0.611) | 27.36 (22.50–32.60) | 84.72 (74.30–92.10) |
| ProGRP+CEA | 0.529 (0.478–0.579) | 85.53 (81.20–89.20) | 27.78 (17.9–39.6) |
| ProGRP+NSE | 0.550 (0.499–0.600) | 38.36 (33.00–44.00) | 79.17 (68.00–87.80) |
| ProGRP+SCCA | 0.574 (0.523–0.623) | 76.10 (71.00–80.70) | 40.28 (28.90–52.50) |
| CEA+NSE | 0.547 (0.496–0.597) | 28.93 (24.00–34.30) | 86.11 (75.90–93.10) |
| CEA+SCCA | 0.565 (0.514–0.615) | 79.25 (74.40–83.60) | 33.33 (22.70–45.40) |
| NSE+SCCA | 0.589 (0.538–0.638) | 60.06 (54.40–65.50) | 55.56 (43.40–67.30) |
| CYFRA21‐1+ProGRP+CEA | 0.503 (0.452–0.553) | 33.02 (27.90–38.50) | 55.56 (43.40–67.30) |
| CYFRA21‐1+ProGRP+NSE | 0.548 (0.497–0.598) | 20.75 (16.40–25.60) | 91.67 (82.70–96.90) |
| CYFRA21‐1+ProGRP+SCCA | 0.571 (0.520–0.620) | 72.64 (67.40–77.50) | 41.67 (30.20–53.90) |
| CYFRA21‐1+NSE+CEA | 0.552 (0.501–0.602) | 20.13 (15.90–25.00) | 93.06 (84.50–97.70) |
| CYFRA21‐1+CEA+SCCA | 0.564 (0.513–0.613) | 57.86 (52.20–63.40) | 54.17 (42.00–66.00) |
| CYFRA21‐1+NSE+SCCA | 0.584 (0.534–0.634) | 58.49 (52.90–64.00) | 56.94 (44.70–68.60) |
| ProGRP+CEA+NSE | 0.548 (0.498–0.599) | 38.99 (33.60–44.60) | 76.39 (64.90–85.60) |
| ProGRP+CEA++SCCA | 0.575 (0.525–0.625) | 70.13 (64.80–75.10) | 45.83 (34.00–58.00) |
| ProGRP+NSE+SCCA | 0.594 (0.543–0.643) | 60.38 (54.80– 65.80) | 56.94 (44.70–68.60) |
| CEA+NSE+SCCA | 0.591 (0.540–0.640) | 30.82 (25.80–36.20) | 86.11 (75.90–93.10) |
| CYFRA21‐1+ProGRP+CEA+NSE | 0.545 (0.494–0.595) | 18.87 (14.70–23.60) | 94.44 (86.40–98.50) |
| CYFRA21‐1+ProGRP+CEA+SCCA | 0.571 (0.520–0.621) | 75.47 (70.40–80.10) | 37.50 (26.40–49.70) |
| CYFRA21‐1+ProGRP+NSE+SCCA | 0.590 (0.540–0.640) | 69.50 (64.10–74.50) | 50.00 (38.00–62.00) |
| CYFRA21‐1+CEA+NSE+SCCA | 0.587 (0.536–0.636) | 74.84 (69.70–79.50) | 40.28 (28.90–52.50) |
| ProGRP+CEA+NSE+SCCA | 0.596 (0.546–0.645) | 36.16 (30.90–41.70) | 81.94 (71.10–90.00) |
| CYFRA21‐1+ProGRP+CEA+NSE+SCCA | 0.593 (0.542–0.642) | 62.58 (57.00–67.90) | 54.17 (42.00–66.00) |