Fig. 7. Oncobiome signatures in HER2+ BCs where high hybridization signals correlated with worse disease outcome.

A The graphs show disease-free rate relative to high or low hybridization signals for the specific microorganisms in the tumor sample set. In the cases shown, higher hybridization signal correlates with decreased disease-free time. These microorganisms detected in patients with lower disease-free rate or survival were not significantly associated with higher cancer staging. B The tumor samples were then clustered based on the hybridization levels for these microorganisms. The low (cluster 1) and the high (cluster 2) hybridization detection clusters correlated with other clinical data shown as horizontal (a–g) and vertical (h) cluster barplot.