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. 2021 Sep 4;6:333. doi: 10.1038/s41392-021-00702-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — LMP1 induces dedifferentiation of NPC-derived cells and enhances tumorigenesis. a Phase contrast images of CNE1-TetOn-Vector (Vector) and CNE1-TetOn-LMP1 (LMP1) cells treated with 100 ng/ml Dox for 48 hours. b, c Immunofluorescence staining with differentiation markers in CNE1-TetOn-Vector and CNE1-TetOn-LMP1 cells treated with 100 ng/ml Dox for 48 hours. d SA-β-gal staining in CNE1-TetOn-Vector and CNE1-TetOn-LMP1 cells treated with 100 ng/ml Dox for 48 hours. e CNE1-TetOn-Vector and CNE1-TetOn-LMP1 cells were injected into nude mice subcutaneously with continuous Dox administration and tumor volume was determined. f Tumor tissue or primary cultured tumor cells obtained by isolating cells from trypsinized tumor tissue were subjected to western blot with the indicated antibodies. g Immunohistochemistry with differentiation markers in tumor from mice with Dox administration. Representative immunohistochemistry images are shown. Statistics (c–e), significance: *P < 0.05, ***P < 0.001; two-tailed Student’s t-tests