Table 1.
Demographic characteristics, clinical data, and BDNF levels in antipsychotics-naive first-episode (ANFE) patients with schizophrenia (SCZ) and healthy controls.
| Variable | ANFE patients (n = 225) | Healthy controls (n = 125) | p value |
|---|---|---|---|
| Gender(male/female) | 124/101 | 77/48 | 0.26 |
| Age (years) | 27.9 ± 9.3 | 27.6 ± 7.0 | 0.90 |
| Education (years) | 9.3 ± 3.9 | 10.3 ± 3.1 | 0.01 |
| Smoker (n, %) | 64 (28.4) | 44 (35.2) | 0.23 |
| Weight (kg) | 59.4 ± 11.7 | 66.7 ± 13.9 | <0.001 |
| BMI (kg/m2) | 21.4 ± 3.5 | 23.5 ± 4.1 | 0.001 |
| Age of onset (years) | 26.2 ± 9.2 | ||
| BDNF(ng/ml) | 9.5 ± 3.9 | 11.8 ± 2.5 | <0.001 |
| BDNF Val66Met | 0.54 | ||
| Met/Met | 55 | 34 | |
| Val/Met | 112 | 54 | |
| Val/Val | 58 | 36 |
BMI body mass index; PANSS the positive and negative syndrome scale; BDNF brain-derived neurotrophic factor.