Table 2.
Changes of BDNF levels and clinical characteristics across three genotypes in ANFE patients with schizophrenia.
| Variable | Val/Val n = 58 | Val/Met n = 112 | Met/Met n = 55 | F (p) |
|---|---|---|---|---|
| Baseline | ||||
| Weight (kg) | 60.9 ± 11.2 | 59.5 ± 12.3 | 57.8 ± 10.7 | 1.0 (0.37) |
| BMI (kg/m2) | 21.8 ± 3.0 | 21.4 ± 3.7 | 21.0 ± 3.5 | 0.7 (0.50) |
| BDNF (ng) | 9.0 ± 3.9 | 9.7 ± 3.5 | 9.7 ± 4.6 | 0.6 (0.56) |
| Age (yrs) | 31.1 ± 10.2 | 26.9 ± 9.0 | 26.5 ± 8.2 | 5.0 (0.01) |
| Education (yrs) | 9.0 ± 4.2 | 9.7 ± 3.7 | 8.8 ± 3.7 | 1.4 (0.25) |
| Onset age (yrs) | 29.1 ± 10.4 | 25.4 ± 8.9 | 24.6 ± 7.9 | 4.3 (0.01) |
| Changes at 12-week follow-up | ||||
| Weight gain (kg) | 2.3 ± 3.4 | 2.6 ± 3.4 | 3.0 ± 4.5 | 0.5 (0.60) |
| BMI gain (kg/m2) | 0.8 ± 1.2 | 1.0 ± 1.2 | 1.1 ± 1.6 | 0.4 (0.68) |
| BDNF levels (ng) | 0.3 ± 4.3 | 0.4 ± 4.4 | 1.7 ± 9.7 | 0.7 (0.52) |
| PANSS total score | 28.8 ± 21.1 | 23.3 ± 17.0 | 25.1 ± 18.3 | 1.6 (0.20) |
| P subscore | 12.2 ± 7.1 | 9.7 ± 6.1 | 9.5 ± 6.3 | 3.2 (0.04) |
| N subscore | 3.9 ± 7.3 | 4.2 ± 5.9 | 5.5 ± 5.7 | 1.0 (0.37) |
| G subscore | 12.8 ± 10.5 | 9.6 ± 9.0 | 10.7 ± 9.5 | 2.0 (0.13) |
P subscore positive subscore, N subscore negative subscore, G subscore general psychopathology subscore.